Award details

Microbial selenium cycling: characterisation of a novel membrane-bound selenate reductase

Reference	BBS/B/10110
Principal Investigator / Supervisor	Dr Clive Butler
Co-Investigators / Co-Supervisors	Professor David Richardson
Institution	Newcastle University
Department	School of Cell and Molecular Biosciences
Funding type	Research
Value (£)	150,945
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2006
Duration	24 months

Abstract

Microbial selenate reduction contributes significantly to the global selenium cycle and is the major process responsible for the reduction of selenate to insoluble elemental selenium. A previous BBSRC research application (13/P17219) has funded a 12-month feasibility study to investigate the enzymology of selenate reduction in Enterobacter cloacae SLD1a-1. We have made significant progress and can now provide direct evidence for a novel molybdenum-dependent membrane-bound selenate reductase (SAM) system that is distinct from the periplasmic selenate reductase (SER) and the membrane bound nitrate reductase (NAR). The bioenergetics, structure and mechanism of SAM will now be investigated in detail using a combination of whole cell physiology, molecular biology, biochemistry and spectroscopy.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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