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Stargazin-microtubule-associating protein complexes and their role in AMPA receptor trafficking and neuronal migration

Reference	BBS/B/09899
Principal Investigator / Supervisor	Dr C Thompson
Co-Investigators / Co-Supervisors
Institution	Durham University
Department	Biological and Biomedical Sciences
Funding type	Research
Value (£)	212,094
Status	Completed
Type	Research Grant
Start date	05/07/2004
End date	04/07/2007
Duration	36 months

Abstract

The ataxic mouse, stargazer (stg), fails to express stargazin. Stg cerebellar granule cells (CGC) subsequently have an abnormal morphology, their post-natal development including migration is retarded and trafficking and synaptic targeting of AMPA receptors (AMPAR) is impaired. By a yeast two-hybrid screen we have identified a raft of novel stargazin-interacting proteins including MAP1A/1B (MAPs). We have shown that MAPs co-associate with stargazin, in vivo,and interact with mature, non synaptic AMPARs. Using biochemical, molecular biological and state-of-the-art imaging technologies we aim to determine the role that MAPs-stargazin complexes play in AMPAR dynamics as well as study their possible role in CGC migration and differentiation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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