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Synthesis transduction export and conservation of 4-quinolone signalling in Pseudomonas and Burkholderia

Reference	BBS/B/09740
Principal Investigator / Supervisor	Professor Paul Williams
Co-Investigators / Co-Supervisors	Professor David Barrett, Professor Miguel Camara, Dr Siri Chhabra, Dr Stephen Diggle
Institution	University of Nottingham
Department	Inst of Infections and Immunity
Funding type	Research
Value (£)	279,217
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/12/2007
Duration	45 months

Abstract

The Pseudomonas aeruginosa diffusible signal molecule, 2-heptyl-4-hydroxy-quinolone (PQS) is an integral part of the N-acylhomoserine lactone (AHL)-dependent quorum sensing network which regulates genes coding for diverse secondary metabolites and virulence determinants. A number of P. aeruginosa genes involved in PQS biosynthesis (pqsABCD, phnAB and pqsH), regulation (pqsR) and action (pqsE and pqsR) have been identified. We propose to build on our previous work on PQS signalling by: (a) defining the roles of PqsABCD and PqsH in PQS synthesis, (b) establishing the mechanism by which PQS signalling is transduced via PqsE, (c) defining the extent of the PQS regulon and its relationship with the AHL-dependent regulon, (d) determining how PQS is exported from the cell, (e) investigating the conservation of PQS signalling in Pseudomonas and Burkholderia.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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