Award details

Recombineering Caenorhabditis elegans reporter gene fusions

Reference	BBS/B/09716
Principal Investigator / Supervisor	Professor Ian Hope
Co-Investigators / Co-Supervisors
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	50,746
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	31/08/2005
Duration	12 months

Abstract

The recently-developed technique of recombinogenic engineering will be extended to allow insertion of reporter genes precisely at the end of the protein coding region of cloned C. elegans genes. As well as reporting accurately on the transcriptional activity of a genes promoter, information on subcellular localisation of the endogenous gene product should also be provided with the C-terminally tagged proteins. The feasibility of using this approach for efficient C. elegans genomic investigation will be tested with a sample of twenty, muscle-specific genes, this tissue specificity being selected because of the structural order of muscle cells.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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