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Proteomic analysis of deafferentation-induced plasticity in medial vestibular nucleus and cerebellum

Reference	BBS/B/09686
Principal Investigator / Supervisor	Professor Mayank Dutia
Co-Investigators / Co-Supervisors	Professor Alastair Aitken
Institution	University of Edinburgh
Department	Biomedical Sciences
Funding type	Research
Value (£)	248,608
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

Medial vestibular nucleus (MVN) neurons rapidly down-regulate their inhibitory receptors (including GABAB receptors), and upregulate their intrinsic excitability, after deafferentation of the vestibular receptors of one inner ear. These changes are likely to be important early in vestibular compensation, a long-standing model of behavioural plasticity in adult brain. We recently identified 5 MVN proteins that show significant changes during compensation, including zebrin/aldolase-C, a molecular marker that compartmentalises the cerebellar cortex. Here we shall a) extend our proteomic analysis of compensatory plasticity in MVN and cerebellum, focussing on membrane- and phospho-proteins; and b) characterise proteins that interact with the GABAB receptor and how these changes during compensation, to determine their role in functional modulation of GABAB efficacy in vivo.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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