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Proteomic analysis of the SCFtir1-Aux/IAA interaction

Reference	BBS/B/09392
Principal Investigator / Supervisor	Professor Ottoline Leyser
Co-Investigators / Co-Supervisors	Dr Stefan Kepinski
Institution	University of York
Department	Biology
Funding type	Research
Value (£)	242,115
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

Auxin signalling is central to the control of plant development. At the hub of auxin signal transduction is the degradation of the Aux/IAA family of transcriptional regulators. Aux/IAAs are targeted for degradation by an SCF-type ubiquitin protein ligase complex called SCFTIR1, which ubiquitinylates the Aux/IAAs, marking them for degradation by the 26S proteosome. Auxin promotes the interaction between the SCFTIR1 and the Aux/IAAs, thus accelerating their degradation. Crucially, the mechanism by which auxin promotes this interaction is completely unknown. This project aims to investigate the regulation of the SCFTIR1-Aux/IAA interaction using a combined genetic, biochemical, and proteomic approach.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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