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Understanding and harnessing multiple herbicide resistance in weeds

Reference	BBS/B/09201
Principal Investigator / Supervisor	Professor Robert Edwards
Co-Investigators / Co-Supervisors	Dr Ian Cummins
Institution	Durham University
Department	Biological and Biomedical Sciences
Funding type	Research
Value (£)	221,439
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	31/10/2007
Duration	38 months

Abstract

We have recently determined that multiple herbicide resistance (MHR) in black-grass is associated with changes in redox homeostasis and flavonoid metabolism suggesting a link with oxidative stress responses. Herbicide safener applications can mimic part of the biochemical changes seen in MHR, but do not enhance herbicide tolerance. We propose to; I) use a biochemical approach to quantitatively define key components of the MHR and safening phenotype using a combination of metabolic profiling, proteomics and subtractive cloning; II) define the cause of the constitutively enhanced expression of an MHR-associated glutathione transferase (GST) and III) elucidate the function of this GST in chemical stress tolerance in transgenic Arabidopsis.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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