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The role of RNA Localisation in I Factor Transposition

Reference	BBS/B/09007
Principal Investigator / Supervisor	Professor David Finnegan
Co-Investigators / Co-Supervisors	Professor Ilan Davis
Institution	University of Edinburgh
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	257,011
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	30/04/2007
Duration	37 months

Abstract

Transposable elements are a major component of most eukaryotic genomes and are one of the most significant drivers of genome evolution. Many can move horizontally between species and must interact with the cellular machinery of their hosts. We shall determine how the RNA transposition intermediate of the I factor, a non-LTR retrotransposon of Drosophila, uses host proteins to move through the oocyte cytoplasm to the nucleus where it is reverse transcribed and integrated in the genome. It is localised by a mechanism similar to that which moves RNA of the developmentally important gene gurken. We shall determine to what extend these RNAs utilise the same transport proteins, the features of the RNA required for movement, the importance of RNA localisation for transposition, and whether the machinery used by the I factor is conserved in distantly related species.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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