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Functional analysis of the adipocyte secreted proteome

Reference	BBS/B/08825
Principal Investigator / Supervisor	Professor Gwyn William Gould
Co-Investigators / Co-Supervisors	Professor Andrew Pitt
Institution	University of Glasgow
Department	School of Life Sciences
Funding type	Research
Value (£)	225,589
Status	Completed
Type	Research Grant
Start date	01/06/2004
End date	31/07/2007
Duration	38 months

Abstract

Adipocytes play a major role in energy metabolism by both paracrine and endocrine mechanisms. In recent years it has been recognised that adipocytes secrete a range of hormones (adipokines) that regulate energy metabolism and insulin sensitivity, e.g. leptin, resistin and adiponectin. These hormones are subject to a major research effort aimed at understanding their role in the development of obesity and insulin resistance. We hypothesise that further examples of important hormones secreted from adipocytes remain to be identified. This proposal seeks to fully catalogue the secreted proteome of adipocytes, and to study the biological role of novel proteins. We will apply proteomics to further our understanding of the mechanism of secretion. Finally, we will develop systems to study the proteome of human adipocytes from different fat depots. Collectively this data will offer new insight into adipocyte physiology, adipokine biology and have potential relevance to the aetiology of multiple human diseases.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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