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Photoperiodic regulation of a neuroendocrine relay in a seasonal mammal: genomic and transcriptional pathways

Reference	BBS/B/08744
Principal Investigator / Supervisor	Professor Andrew Loudon
Co-Investigators / Co-Supervisors	Professor Julian Davis
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	514,432
Status	Completed
Type	Research Grant
Start date	30/06/2004
End date	29/06/2008
Duration	48 months

Abstract

This proposal focuses on the seasonal prolactin response, as the best current target for understanding photoperiodic regulation of the neuroendocrine axis. Melatonin action on specialised receptors within the pars tuberalis (PT) region of the pituitary gland regulates hormone secretion. With the PT as our focus: 1) We will use phage panning to isolate candidate prolactin-releasing peptides from the PT, identify their molecular nature in order to define melatonin-regulated gene(s) driving this seasonal endocrine pathway. 2) We will use cDNA arrays (both PT-enriched arrays and bovine brain arrays) to determine for the first time the nature and extent of genomic changes in a melatonin target site and define key signalling pathways involved.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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