Award details

Immunological consequences of the interaction of enterohemorrhagic E. coli with the organised lymphoid tissues of the gut

Reference	BBS/B/08566/2
Principal Investigator / Supervisor	Professor Thomas MacDonald
Co-Investigators / Co-Supervisors	Professor Gad Frankel
Institution	Queen Mary University of London
Department	Sch of Medicine & Dentistry
Funding type	Research
Value (£)	146,254
Status	Completed
Type	Research Grant
Start date	31/01/2006
End date	30/06/2008
Duration	29 months

Abstract

Attaching and effacing Enterohemorrhagic E.coli (EHEC) in cattle and man, enteropathogeneric E.coli in man and rabbits and Citrobacter rodentiumin mice all show tropism for the surface of the organised lymphoid tissue of the gut. Other data suggests that EPEC and intimin can down-regulate or activate cells of the immune system. We propose that the tropism of these bacteria for the organised lymphoid tissue of the gut is to allow the organisms to modulate host responses and compromise mucosal anti-bacterial immunity. In this work we will investigate whether EHEC can modulate dendritic cell (DC) function in human Peyers patches using ex vivo culture models, and investigate their direct interaction with the myeloid dendritic cells which lie below the follicle epithelium and which send processes onto the surface of the follicles.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, Immunology, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/08566 Immunological consequences of the interaction of enterohemorrhagic E. coli with the organised lymphoid tissues of the gut

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