Award details

Immunological consequences of the interaction of enterohemorrhagic E. coli with the organised lymphoid tissues of the gut

Reference	BBS/B/08566
Principal Investigator / Supervisor	Professor Thomas MacDonald
Co-Investigators / Co-Supervisors	Professor Gad Frankel
Institution	University of Southampton
Department	Inflammation Infection and Repair
Funding type	Research
Value (£)	196,475
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/07/2005
Duration	16 months

Abstract

Attaching and effacing Enterohemorrhagic E.coli (EHEC) in cattle and man, enteropathogeneric E.coli in man and rabbits and Citrobacter rodentiumin mice all show tropism for the surface of the organised lymphoid tissue of the gut. Other data suggests that EPEC and intimin can down-regulate or activate cells of the immune system. We propose that the tropism of these bacteria for the organised lymphoid tissue of the gut is to allow the organisms to modulate host responses and compromise mucosal anti-bacterial immunity. In this work we will investigate whether EHEC can modulate dendritic cell (DC) function in human Peyers patches using ex vivo culture models, and investigate their direct interaction with the myeloid dendritic cells which lie below the follicle epithelium and which send processes onto the surface of the follicles.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/08566/2 Immunological consequences of the interaction of enterohemorrhagic E. coli with the organised lymphoid tissues of the gut

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