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Predicting human sleep timing performance rhythms and circadian physiology from a polymorphism in the clock gene HPer3

Reference	BBS/B/08523
Principal Investigator / Supervisor	Professor Derk-Jan Dijk
Co-Investigators / Co-Supervisors	Professor Simon Archer, Professor Debra Skene, Professor Malcolm von Schantz
Institution	University of Surrey
Department	Health and Medical Sciences
Funding type	Research
Value (£)	156,186
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	30/06/2006
Duration	24 months

Abstract

Inter-individual differences in sleep timing, diurnal preference and physiological rhythms are related to differences in the biological clock, which in turn relate to genetic differences in expression cycles of an individuals clock genes. We have demonstrated an association between the frequency of a length polymorphism in the clock gene hPer3 and extreme diurnal preference, and delayed sleep phase syndrome. The objective of the proposed work is to characterise the physiological and behavioural consequences of this polymorphism. This will be achieved by quantifying circadian phase, sleep timing and sleep structure, and the rhythms of alertness and performance, in healthy volunteers selected for two homozygous hPer3 genotypes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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