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Analysis of sterol-mediated regulation of START domain transcription factors in Arabidopsis

Reference	BBS/B/08418
Principal Investigator / Supervisor	Professor Keith Lindsey
Co-Investigators / Co-Supervisors	Dr Jennifer Topping
Institution	Durham University
Department	Biological and Biomedical Sciences
Funding type	Research
Value (£)	249,729
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

One of the most exciting questions in plant developmental biology is how plant cells respond to developmental cues to produce patterned tissues and organs. While many factors that influence pattern formation are known, one aspect for which there is little information is the role of sterols. The hydra1 and hydra2 mutants of Arabidopsis are defective in sterol biosynthesis, and meristem function and tissue organisation. These mutants provide ideal tools to study the role of sterols in plant organogenesis. Since the hybrid mutants have abnormal sterol profiles, and sterols can modulate transcription, it is proposed to relate the expression, localisation and function of putative sterol-dependent transcription factors to the control of development.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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