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Genetic control of learning behaviour: Characterisation of downstream genes regulated by zif/268

Reference	BBS/B/07993
Principal Investigator / Supervisor	Professor Brian Morris
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	Institute of Biomedical & Life Sciences
Funding type	Research
Value (£)	129,929
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	31/03/2005
Duration	13 months

Abstract

The transcription factor zif/268 (egr1) is induced in many models of learning behaviour across many animal species. However, the target gene which it affects, which are likely to be responsible for maintaining the altered neuronal network activity, have not been identified. Using Affymetrix gene arrays, we have recently identified a number of potential neuronal zif/268 target genes, both known genes and novel sequences, which fall into clear functional classes. This project aims to validate the evidence linking induction of these genes to zif/268, and to characterise the role of these genes in hippocampal plasticity. The results should dramatically increase our understanding of learning mechanisms at the molecular and cellular level.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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