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Dorsal closure in Drosophila as a model system for the identification of genes regulating epithelial cell behaviour
Reference
BBS/B/07977
Principal Investigator / Supervisor
Professor Alfonso Martinez Arias
Co-Investigators /
Co-Supervisors
Dr David Robert Micklam
Institution
University of Cambridge
Department
Genetics
Funding type
Research
Value (£)
246,918
Status
Completed
Type
Research Grant
Start date
01/06/2004
End date
31/12/2007
Duration
43 months
Abstract
Dorsal closure is a morphogenetic process that occurs during late Drosophila embryogenesis, sealing a hole on the dorsal side of the embryo, and producing a continuous epidermis. The process relies on coordinated cell movements between different epithelial sheets. In particular the spatial and temporal regulation of actin dynamics in the epidermis is a crucial element of the process. Genetic analysis has shown that signalling through JNK and Jun/Fos (AP1) heterodimers provides a driving force for these cellular activities. Here we propose to identify and characterise genes that are associated with and regulated by JNK and AP1 during dorsal closure. To do this we shall use classical genetic analysis a novel targeted microarray technique.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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