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Characterisation of a plant gene with potential natural antisense regulation

Reference	BBS/B/07802
Principal Investigator / Supervisor	Professor Peter Meyer
Co-Investigators / Co-Supervisors	Dr Elena Zubko
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	264,053
Status	Completed
Type	Research Grant
Start date	01/03/2004
End date	28/02/2007
Duration	36 months

Abstract

Cytokinin synthesis plays an essential role in growth control, but also in habituation and epigenetic gene regulation. The Sho gene from Petunia hybrida is responsible for cytokinin synthesis. The gene contains two partly overlapping, opposite open reading frames, and it is flanked by two inversely oriented promoters. Pilot experiments have shown that both sense and antisense transcripts are made. This implies that natural occurring antisense transcription may be involved in the regulation of the expression of this gene. We propose to examine the molecular mechanisms involved in Sho expression to test the hypothesis that Sho is regulated by a post-transcriptional gene silencing mechanism.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrated Epigenetics (EPI) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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