Award details

System-specific chaperones on the Tat protein transport pathway

Reference	BBS/B/07780
Principal Investigator / Supervisor	Professor Frank Sargent
Co-Investigators / Co-Supervisors	Professor David Richardson
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	207,582
Status	Completed
Type	Research Grant
Start date	01/06/2004
End date	31/01/2007
Duration	32 months

Abstract

The twin-arginine protein transport (Tat) system is a remarkable molecular machine dedicated to the translocation of fully folded proteins across energy-transducing membranes. Cofactor-containing Tat substrates such as trimethylamine N-oxide reductase acquire their cofactors prior to export and substrate proteins actually require to be folded before transport can proceed. Thus it is very likely that mechanisms exist to prevent wasteful export of immature Tat substrates or curb competition between immature and mature substrates for the transporter. Using the model prokaryote Escherichia coli and the TorD molecular chaperone system, we will define the proofreading activity on the Tat pathway at the molecular and cellular levels.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/07780/2 System-specific chaperones on the Tat protein transport pathway

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