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The molecular basis of anthelmintic resistance in parasitic nematodes and the development of rapid detection systems
Reference
BBS/B/07594
Principal Investigator / Supervisor
Dr Adrian John Wolstenholme
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Biology and Biochemistry
Funding type
Research
Value (£)
205,098
Status
Completed
Type
Research Grant
Start date
01/07/2004
End date
30/06/2007
Duration
36 months
Abstract
Parasitic nematodes are a major threat to UK livestock and resistance to currently used treatments is growing. We will study the molecular basis of anthelmintic resistance in T. circumcincta and H. contortus to produce quantitative PCR assays for the detection of resistance alleles. For benzimidazole resistance, the assay will be based on identified mutations in beta-tubulin genes. For levamisole resistance, where no candidate mutation has been proposed, we look for changes in the nicotinic receptor target site and will also take a proteomics approach to identify genes whose expression changes in resistance worms or following drug treatment. For invermectin resistance, we will use functional genomics techniques to test candidate resistance genes.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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