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Axis formation and early embryonic patterning in arthropods
Reference
BBS/B/07519
Principal Investigator / Supervisor
Professor Michael Akam
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Zoology
Funding type
Research
Value (£)
304,830
Status
Completed
Type
Research Grant
Start date
01/12/2004
End date
30/11/2008
Duration
48 months
Abstract
In Drosophila, localised maternal determinants and signals lead to initial asymmetries in the fertilised egg, which through a hierarchical cascade of transcriptional interactions lead to regionalisation and segmentation of the embryo. It is now clear that the same mechanisms do not operate in all arthropods. We seek to determine to what extent the Drosophila paradigm can be applied to other arthropods, and what mechanisms operate in those species where the Drosophila paradigm fails. Specifically, we shall examine the specification of embryonic and extra-embryonic territories and the evolving role of Zen genes in this process, and the possible involvement of Notch related mechanisms in the segmentation of myriapods, basal insects and crustaceans.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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