Award details

Investigating microRNA-regulated gene silencing in Arabidopsis thaliana

Reference	BBS/B/07446
Principal Investigator / Supervisor	Professor Keith Edwards
Co-Investigators / Co-Supervisors	Dr Gary Barker, Dr Ian Wilson
Institution	University of Bristol
Department	Biological Sciences
Funding type	Research
Value (£)	247,751
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	31/01/2008
Duration	43 months

Abstract

The involvement of micro RNAs (miRNAs) in regulating gene expression will be investigated in Arabidopsis thaliana. A bioinformatics approach has been used to identify novel miRNA sequences from within the Arabidopsis genome. The potential messenger RNA (mRNA), targets of some of the miRNAs have also been identified. Expression profiles for both the miRNAs and their target mRNAs will be determined. Using both transgenic reporter gene approaches the ability of the miRNAs to effect gene silencing will be determined as will the effect of the loss and/or gain of function of their target mRNAs. The information obtained will be useful in aiding the development of novel tools required to manipulate key areas of plant development.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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