Award details

The interplay of transcription factors and chromatin modifiers at target genes in vivo

Reference	BBS/B/07438
Principal Investigator / Supervisor	Professor Constanze Bonifer
Co-Investigators / Co-Supervisors	Dr Svetlana Melnik
Institution	University of Leeds
Department	School of Medicine
Funding type	Research
Value (£)	288,979
Status	Completed
Type	Research Grant
Start date	01/11/2004
End date	31/10/2007
Duration	36 months

Abstract

Cell fate determination culminates in the activation of genes characteristic for the terminally differentiated state and the stable repression of genes associated with alternative cell fates. These global changes in gene expression are induced by regulatory protein complexes that influence the transcriptional status of large arrays of genes by altering the spectrum of epigenetic marks attached to their chromatin. In this proposal we plan we apply novel techniques to gain insight in how the balance between activating and repressing epigenetic enzyme complexes interacting with specific genes is regulated during cell fate determination processes in the hematopoietic system. We are particularly interested in understanding how these proteins regulate the coordinated switch from repressed to an activated chromatin state.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrated Epigenetics (EPI) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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