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Establishment of methylation patterns in the mouse oocyte
Reference
BBS/B/07403
Principal Investigator / Supervisor
Professor Colum Walsh
Co-Investigators /
Co-Supervisors
Institution
University of Ulster
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
219,784
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
30/04/2007
Duration
36 months
Abstract
Mouse oocytes become methylated on imprinted genes during the growth phase of their development. We aim to determine the effects of oocyte growth in vitro under a variety of conditions on the methylation status of both imprinted genes and repetitive DNA elements. In addition, we will use RNAi knockdown approaches to determine the requirement for Dnmt3a and Dnmt3b proteins in vitro and in vivo and if possible which isoforms are needed. Finally, we will screen growing oocytes for other genes which may be involved in regulating methylation with a view to perturbing their expression in the oocyte in a similar fashion.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integrated Epigenetics (EPI) [2003]
Funding Scheme
X – not Funded via a specific Funding Scheme
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