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Role of the novel MTP transporter family in plant heavy metal homeostasis
Reference
BBS/B/07357
Principal Investigator / Supervisor
Professor Dale Sanders
Co-Investigators /
Co-Supervisors
Dr Damien Blaudez
,
Professor Frans Maathuis
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
253,177
Status
Completed
Type
Research Grant
Start date
01/07/2004
End date
30/06/2007
Duration
36 months
Abstract
Metal Transport Proteins (MTPs) play a critical role in removing transition metals from the cytosol, either by intracellular sequestration or by export from the cell. Despite potential importance of MTPs in phytoremediation and improvement of crop nutrition, the diverse family of 12 MTPs in Arabidopsis remains almost completely uncharacterised. Building on our recent results, we will determine (a) cation specificity among diverse members of the MTP family by expression in yeast; (b) energetic mechanism; (c) intracellular and cellular localisation in planta; (d) function in planta with mutants and overexpressors; (e) residues conferring cation selectively with random mutagenesis.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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