Award details

Changes in information transmission at an auditory synapse in the binaural pathway during short-term synaptic modulation

Reference	BBS/B/07276
Principal Investigator / Supervisor	Professor Ian Forsythe
Co-Investigators / Co-Supervisors
Institution	University of Leicester
Department	Cell Physiology and Pharmacology
Funding type	Research
Value (£)	207,943
Status	Completed
Type	Research Grant
Start date	01/08/2004
End date	31/03/2008
Duration	44 months

Abstract

The information required for sound source localisation is carried in the firing times of neurones in brain stem auditory nuclei. These neurones exhibit synaptic and cellular specialisations that contribute to precisely timed electrical signalling. We will investigate the information transmission characteristics of the glutamatergic calyx of Held synapse in the mammalian MNTB via a combination of mathematical modelling, computer simulation and physiological experiments. We will determine whether multiple forms of short term synaptic modulation interact to alter, and perhaps optimise, information transmission through this pathway in response to behaviourally-relevant sound stimuli, tuning it to aid in sound source localisation. (Joint with BBS/B/07217)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/07217 Changes in information transmission at an auditory synapse in the binaural pathway during short-term synaptic modulation

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