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The role of the U-box protein U76p in regulating the cell death signalling complex and disease resistance in plants

Reference	BBS/B/07152
Principal Investigator / Supervisor	Professor Ari Sadanandom
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	188,706
Status	Completed
Type	Research Grant
Start date	26/07/2004
End date	25/09/2006
Duration	26 months

Abstract

Successful block of pathogen invasion depends upon plants ability to perceive the threat and emit signals to activate defence responses. Hypersensitive cell death response (HR) is an important downstream defence mechanism in plants. Little is known of the biochemistry of the signalling cascades leading up to HR. We have identified a U-box protein that is required for the signalling mechanism in Cf-9/Avr-9 mediated hypersensitive cell death. Using biochemical and cytological techniques we will elucidate the function of u76p in the HR activated by Cf-9/Avr-9 interaction. Yeast two-hybrid screens with u76p as bait will be employed to isolate key proteins governing signalling pathways that trigger HR. Some of these molecules are likely to be negative regulators of the HR signalling complex that are selectively degraded by the proteasome in response to pathogen attack.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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