Award details

Proteomic analysis of the novel proteins associated with the polyoma virus T-antigens and their role in cell function

Reference	BBS/B/06962
Principal Investigator / Supervisor	Professor Stephen Dilworth
Co-Investigators / Co-Supervisors	Dr Graham Taylor
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	277,927
Status	Completed
Type	Research Grant
Start date	25/10/2004
End date	24/10/2007
Duration	36 months

Abstract

A series of protein-protein interactions plays a major part in the signalling pathways that control cell multiplication, differentiation and death. A linear sequence for many of these pathways has been established, but it is clear that bifurcation occurs at a number of points, so new interactions between signalling molecules are still emerging. Here, we plan to use a simple model system, the polyoma T-antigens, to study the initiating events in the pathways that control cell division and senescence. Proteomic approaches will be used to characterise the proteins bound to each T-antigen, and then targeted mutations and siRNA knockdowns employed to determine how each interaction affects cell behaviour.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search