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Regulatory roles of acyl CoA esters in cellular processes in plants
Reference
BBS/B/06784
Principal Investigator / Supervisor
Professor Ian Graham
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
227,214
Status
Completed
Type
Research Grant
Start date
13/09/2004
End date
12/01/2008
Duration
40 months
Abstract
Acyl CoA esters have been shown to be involved in regulating metabolism and cell signalling in bacteria, yeast and mammalian cells but little is known about their role in plants. We have found that altered acyl CoA profiles correlate with altered peroxisome morphology in several Arabidopsis mutants disrupted in peroxisomal fatty acid Beta-oxidation. Further more Tween ester treatments result in a specific induction in genes and enzymes invulved in fatty acid beta oxidation in Arabidopsis leaves. This application aims to manipulate in-vivo acyl CoA levels and establish the effects on peroxisome morphology and related gene expression. The study will then be extended to the transcriptome in order to establish the global nature of the response of plant gene expression to altered levels of acyl CoA metabolites.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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