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Control of carbon assimilation by the fungal pathogen Candida albicans

Reference	BBS/B/06679
Principal Investigator / Supervisor	Professor Al Brown
Co-Investigators / Co-Supervisors	Professor Neil Andrew Robert Gow, Professor Frank Christopher Odds
Institution	University of Aberdeen
Department	School of Medical Sciences
Funding type	Research
Value (£)	395,122
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	30/09/2007
Duration	39 months

Abstract

Candida albicans is the major fungal pathogen of humans. The rapid growth of this fungus in its host is dependent upon its ability to assimilate carbon efficiently. Remarkably little is known about the substrates that C. albicans exploits in vivo, or about the control of carbon assimilation in this fungus. Hence, we will combine our established proteomics facilities with other state-of-the-art molecular and cellular technologies to: (1) define which pathways of carbon assimilation are repressed by physiologically relevant concentrations of glucose; (2) establish which of these pathways are required for the development of systemic candidiasis; and (3) determine the contributions of key regulators to the control of carbon assimilation in vitro and in vivo. In this way we will generate completely novel insights into the growth of this important pathogen within its host.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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