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Structural analysis of substrate and inhibitor specificity of foot-and-mouth disease virus 3C protease

Reference	BBS/B/06547
Principal Investigator / Supervisor	Professor Stephen Curry
Co-Investigators / Co-Supervisors	Professor Robin Leatherbarrow
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	206,089
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	30/09/2007
Duration	39 months

Abstract

Animal viruses are widespread causes of infectious diseases that have serious economic consequences for the livestock industry. Having obtained crystals, we propose (1) to determine the crystal structure of an enzyme required for replication of an important viral pathogen. We also aim (2) to investigate the substrate binding specificity in an extensive series of assays and (3) to use the derived information to design substrate-mimetic inhibitors capable of binding covalently to the enzyme in order to determine enzyme-inhibitor co-crystal structures. This will yield detailed new insights into the enzyme mechanism and provide valuable information to guide future inhibitor design.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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