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The role of the expression of beta-catenin and gamma-catenin in postmitotic neurons in the formation of spinal motor circuitry

Reference	BBS/B/06512
Principal Investigator / Supervisor	Professor Stephen Price
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	252,028
Status	Completed
Type	Research Grant
Start date	18/08/2004
End date	17/08/2007
Duration	36 months

Abstract

Motor neurons are critical to the control of vertebrate motor behaviour. Their organisation within the spinal cord and the specific interactions they make both with themselves and with proprioceptive sensory neurons underpins our ability to move. We have shown that expression of the cell adhesion receptor family of cadherins is of crucial importance in determining the specificity of these contacts. We shall investigate a role in postmitotic neurons for Beta- and gamma-catenins, two key effecters of cadherin-signalling, in the formation of this circuit. To achieve this goal, we shall employ gain and loss of function experiments in vivo, adhesion studies in an in vitro model system and perform a screen for catenin downstream signalling molecules.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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