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Using human embryonic stem cells to model developmental programming by nutrient-epigenetic interactions

Reference	BBS/B/06164
Principal Investigator / Supervisor	Professor Lorraine Young
Co-Investigators / Co-Supervisors	Professor Kevin Sinclair
Institution	University of Nottingham
Department	Div of Obs & Gynaecology
Funding type	Research
Value (£)	331,475
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

We hypothesise that the mechanism through which metabolic response to diet and susceptibility to age related diseases in adult humans is programmed by nutritional status in utero is through epigenetic alterations in DNA methylation. To test this we will examine the effects of specific nutritional components of the methyl cycle on DNA, methylation in human embryonic stem cells and their cardiomyocyte derivatives, modelling the effects on the preimplantation embryo. The effects of relevant methyl donor enzyme polymorphisms (known to predispose adult cardiovascular disease) will be determined to investigate the genetic basis of inter-individual variation in nutritional response.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrated Epigenetics (EPI) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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