Award details

CHORD-mediated macromolecular complexes: Structural and functional analysis

Reference	BBS/B/06148
Principal Investigator / Supervisor	Professor Geoffrey Robert Moore
Co-Investigators / Co-Supervisors
Institution	University of East Anglia
Department	Sainsbury Laboratory
Funding type	Research
Value (£)	409,943
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/07/2007
Duration	40 months

Abstract

Plant RAR1 that contains two zinc-binding CHORD domains mediates disease resistance against various pathogens. These CHORD domains associate with components of the protein folding- and degradation-machinery including SGT1 and HSP90. This grant aims to determine the structure of each CHORD domain and intact RAR1. Furthermore, we will elucidate interaction surfaces and other molecular details of the SGT1-CHORD-II interaction and the HSP90-CHORD-1 interaction. We will also assess whether an HSP90-RAR1-SGT1 ternary complex forms and whether the structure of RAR1 and its affinity for partner proteins changes during resistance activation. (Joint with BBS/B/13241).

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/13241 Chord-mediated macromoleular complexes: structural and functional analysis

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