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Protein glycosylation in Streptomyces coelicolor A3(2)
Reference
BBS/B/05990
Principal Investigator / Supervisor
Professor Margaret Smith
Co-Investigators /
Co-Supervisors
Professor Gurdyal Besra
,
Professor Anne Dell
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
365,866
Status
Completed
Type
Research Grant
Start date
27/09/2004
End date
26/09/2007
Duration
36 months
Abstract
The existence of glycoproteins in bacteria is now accepted as a general phenomenon but little is understood about their structure, biosynthesis and biological functions. This project addresses a putative general O-glycosylation pathway, analogues to the O-mannosylation pathway in fungi, for protein modification in the model soil organism Streptomyces coelicolor A3(2). We will use a multidisciplinary approach to obtain direct evidence for protein glycosylation in S. coelicolor, to elucidate their biosynthesis and structure, and to study the biological roles of glycoproteins during the growth of this organism.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme
X – not Funded via a specific Funding Scheme
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