Award details

Evaluation of selection-mapping methods for QTL localisation

Reference	BBS/B/05710
Principal Investigator / Supervisor	Professor John Woolliams
Co-Investigators / Co-Supervisors	Dr Pamela Wiener
Institution	The Roslin Institute
Department	Genetics and Genomics
Funding type	Research
Value (£)	215,688
Status	Completed
Type	Research Grant
Start date	01/08/2004
End date	31/10/2007
Duration	39 months

Abstract

This study is an examination of the patterns of diversity at and near genes believed to be under selection and the evaluation of several methods of data analysis for detecting signatures of selection. We propose to characterise the diversity at three genes with large phenotypic effect (DGAT1, MC1R and GDF-8) relative to genome-wide diversity in 10 breeds of British cattle. Simulated data will also be used to evaluate the efficacy of several methods of data analysis. Using the results from the simulated data, we will apply the most powerful method(s) to the cattle data and evaluate whether there is evidence for selection at one or more of the genetic loci examined. If successful, this approach will allow genetic loci that encode strongly selected traits to be identified within existing populations.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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