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U-box proteins in disease resistance signalling
Reference
BBS/B/05664
Principal Investigator / Supervisor
Professor Jonathan Jones
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
208,109
Status
Completed
Type
Research Grant
Start date
01/04/2004
End date
31/03/2007
Duration
36 months
Abstract
Biochemical mechanisms that regulate disease resistance in plants are the subject of intense investigation. We recently showed that RAR1 and SGT1 are essential for resistance conferred by a number of resistance genes. These proteins interact with each other and form complexes with ubiquitin ligase subunits and the COP9 signalosome, suggesting ubiquitination may be involved in controlling resistance responses. In this project we focus on a RAR1 interacting proteins termed AtPUB20 and AtPUB21 (plant U-box protein), which contain a U-box domain and a leucine rich domain similar to armadillo repeats. We combine genetic analysis, cellular biology tools and protein biochemistry to characterise the function of AtPUB20 and AtPUB21 at the early stage of signal transduction leading to disease resistance.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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