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The structure of K-channel/ PSD95 complexes in the Post Synaptic Density
Reference
BBS/B/05567
Principal Investigator / Supervisor
Dr Stephen Prince
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
250,759
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
31/05/2007
Duration
37 months
Abstract
We will elucidate the 3-dimensional atomic structure and quantify the binding affinity of complexes of PDZ interaction modules from the scaffold protein PSD95 with an array of Potassium channels. The membrane associated PSD95 protein is known to cluster and stabilise both inwardly rectifying and voltage gated K+ channels in the post-synaptic membrane. Together these channels are determinants of neuronal excitability and plasticity. This study will define the specificity of PSD95 mediated clustering of this class of channel and provide a model for the interaction of scaffold proteins with membrane channels in general.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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