Award details

Mouse to Arabidopsis: transkingdom approaches to discovery of imprinted genes and analysis of genomic context

Reference	BBS/B/05532
Principal Investigator / Supervisor	Professor Roderick Scott
Co-Investigators / Co-Supervisors	Professor Laurence Hurst, Dr Gavin Kelsey, Professor Rebecca Oakey
Institution	University of Bath
Department	Biology and Biochemistry
Funding type	Research
Value (£)	366,548
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

Imprinting is an epigenetic mechanism regulating parent-specific gene expression and is crucial in reproduction for mammals and flowering plants. In mammals imprinting breakdown is linked to disease and cloning failure; in plants imprinting affects agronomic traits such as seed size and breeding barriers. There are many imprinted genes known in mouse but few in plants. We aim to 1) discover novel imprinted genes in the model plant Arabidopsis using molecular and bioinformatics techniques successful in mouse; 2) develop bioinformatics tools to extend analysis of mouse sequence, expression, and epigenetic data and apply this to Arabidopsis; 3) begin to compare genomic sequence and epigenetic features of imprinting across the two kingdoms.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrated Epigenetics (EPI) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search