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Genetic screens for novel polycomb-group genes in Arabidopsis

Reference	BBS/B/05494
Principal Investigator / Supervisor	Dr Justin Goodrich
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell Biology
Funding type	Research
Value (£)	69,714
Status	Completed
Type	Research Grant
Start date	21/06/2004
End date	20/06/2007
Duration	36 months

Abstract

Polycomb-group (Pc-G) genes control cell fate in plant and animals by mediating mitoitically stable states of homeotic gene expression. However, in plants, cell fates can be reprogrammed relatively easily compared to animals. This suggests that there are differences in the mechanism of Pc-G action between plants and animals. The Pc-G genes that confer an epigenetic mark, methylation of specific lysine residues on histone H3, are conserved between plants and animals. However, the genes that interpret this mark and convert it to transcriptional repression in animals are not conserved, suggesting that plants use different genes. To identify these genes, genetic screens are proposed using customised genetic backgrounds.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrated Epigenetics (EPI) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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