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Molecular characterisation of the processes responsible for toxigenic conversion of E. coli by VT-bacteriophages

Reference	BBS/B/05265
Principal Investigator / Supervisor	Dr Heather Allison
Co-Investigators / Co-Supervisors	Professor Alan McCarthy, Professor Jonathan Saunders
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	176,063
Status	Completed
Type	Research Grant
Start date	02/08/2004
End date	01/08/2007
Duration	36 months

Abstract

Verocytotoxin genes are carried and spread by a heterogeneous group of lambdoid bacteriophages, the VT-phages. It has been assumed that these phages will behave similarly to lambda phage, but we have evidence that both the infection processes and the immunity mechanisms are distinct and have important implications for pathogenicity. We will use our established VT-phage model to characterise the initial events following V-phage contact with a potential host cell - essentially the mechanisms that dictate binding to the bacterial host cell, phage immunity and integration into the host genome to produce a toxigenic lysogen. We will exploit our bank of VT-phages from different clinical, animal and environmental sources to identify and compare the diversity of mechanisms controlling these events in E. coli populations.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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