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Mechanisms underlying the modulatory actions of cytochrome P450-derived eicosanoids in human myometrium

Reference	BBS/B/05125
Principal Investigator / Supervisor	Professor Raheela N Khan
Co-Investigators / Co-Supervisors	Professor David Barrett, Dr Balwir Matharoo-Ball
Institution	University of Nottingham
Department	Div of Obs & Gynaecology
Funding type	Research
Value (£)	226,487
Status	Completed
Type	Research Grant
Start date	01/11/2004
End date	31/10/2007
Duration	36 months

Abstract

Epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoics acids (HETEs) are produced by the cytochrome P450-mediated metabolism of arachidonic acid. These eicosanoids have potent effects through their effects on ion channels, in particular, the high-conductance calcium-activated potassium channel (BKCa). The presence of EETs and the BKCa channel in human myometrium suggests regulation of myometrial excitability. We will use complementary techniques (mass spectrometry, western blotting, tension recordings and electrophysiology) to analyse the production of these eicosanoids and to investigate their modulatory effects in human myometrium. This study will shed light on the interaction between the EETs/HETEs and ion channels in the transition of myometrium from a quiescent to a contractile state with labour.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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