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Extracellular calcium sensing in intestinal mineral absorption

Reference	BBS/B/04986
Principal Investigator / Supervisor	Dr Donald Ward
Co-Investigators / Co-Supervisors	Dr Martin Steward
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	270,285
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	31/10/2007
Duration	38 months

Abstract

Dietary calcium enters the body by intestinal absorption, a process requiring vitamin D and parathyroid hormone. In the parathyroid glands and kidney, the calcium-sensing receptor (CaR) responds to raised blood Ca2+ levels of inhibiting the production of actions of these hormones. The CaR is also expressed on the serosal surface of intestinal epithelium, however its role there remains unclear. From existing evidence we hypothesise that the intestinal CaR inhibits Ca2+ absorption as a protective negative feedback mechanism and, furthermore, that it may also mediate extracellular Ca2+ induced enterocyte differentiation. Through the use of CaR knock-out mice and human intestinal cell lines this project will determine the acute and chronic responses to extracellular Ca2+ in the intestine and enhance our understanding of calcium homeostasis and its adaption to diet.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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