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Mammalian microRNAs retrotransposons and genomic imprinting
Reference
BBS/B/04919
Principal Investigator / Supervisor
Professor Anne Ferguson-Smith
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Physiology Development and Neuroscience
Funding type
Research
Value (£)
301,758
Status
Completed
Type
Research Grant
Start date
18/06/2004
End date
17/06/2007
Duration
36 months
Abstract
MicroRNAs are an abundant class of RNA that are 20-25 nucleotides long, interact with target mRNAs and trigger either translational repression, RNA cleavage, or epigenetic modification. We recently identified the first two animal microRNAs with 100 per cent complementarity to an endogenous murine gene. This putative target mRNA is a retrotransposon-like gene (Rtl1) that is subject to genomic imprinting and located within a 1 Mb imprinted domain on distal mouse chromosome 12. Here we propose to determine the potential link between endogenous miRNAs, retrotransposon silencing and genomic imprinting by characterising the functional link between the miRNAs and Rtl1, and determining potential epigenetic consequences of such an interaction.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integrated Epigenetics (EPI) [2003]
Funding Scheme
X – not Funded via a specific Funding Scheme
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