BBSRC Portfolio Analyser
Award details
Regulation of C. elegans behaviour by a family of NPY-like receptors
Reference
BBS/B/04439
Principal Investigator / Supervisor
Professor Lindy Holden-Dye
Co-Investigators /
Co-Supervisors
Dr Neline Kriek
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
379,134
Status
Completed
Type
Research Grant
Start date
01/03/2004
End date
31/03/2008
Duration
49 months
Abstract
An animals behavioural state depends on its environment. The simple animal C. elegans is no exception to this, e.g. on food it slows down and lays eggs. As in higher animals, it is evident that NPY-like receptors and neuropeptides play an important role in these context-dependent behaviours. We have identified 12 NPY-like receptors in C. elegans; and by RNAi shown at least 6 regulate locomotion and egg-laying. We will map these, and their cognate ligands, to neuronal circuits and define their function by cell specific gene knock-out and overexpression. The aim is to uncover general principles in the role of peptide signalling in the control of behaviour that can be applied to higher animals that are less amendable to genetic analysis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search