Award details

Quantitative on-line assessment of collagen fibre organisation in connective tissues in vivo and during tissue engineering in vitro

Reference	BBS/B/04277
Principal Investigator / Supervisor	Professor Alicia El Haj
Co-Investigators / Co-Supervisors	Professor Nicola Maffulli, Professor Ying Yang
Institution	Keele University
Department	Sch of Medicine
Funding type	Research
Value (£)	170,806
Status	Completed
Type	Research Grant
Start date	01/09/2004
End date	29/02/2008
Duration	42 months

Abstract

The aim of this project is to develop a novel and flexile fibre optic based system for providing accurate and high resolution information on the birefringence properties of connective tissues. The project combines an in vitro and in vivo approach making use of the strengths of the interdisciplinary team from Cranfield and Keele. In particular, the combined approach of instrumentation development for on-line monitoring, theoretical modelling of multiple scattering and coherence gating, with biological cartilage and tendon tissue models in vitro and clinical biopsies from normal and pathological tissues provides the critical elements for developing this technology. The on-line monitoring system for tissue architecture construction in vitro will have applications in tissue engineering and provide a potential tool for monitoring connective tissues in patients during orthopaedic surgery. (Joint with BBS/B/04242)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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