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Exploitation of mesenchymal cell plasticity using RNA interference technology for tissue regeneration

Reference	BBS/B/04269
Principal Investigator / Supervisor	Professor Richard Oreffo
Co-Investigators / Co-Supervisors	Professor David O'Connor, Dr Junlong Zhang
Institution	University of Southampton
Department	Development Origin of Health and Disease
Funding type	Research
Value (£)	201,385
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

Given the demographic challenge of an ageing population, the development of facile platform technologies for the isolation of progenitor/cell populations for use in tissue regeneration is an urgent medical need. We propose that by using human bone marrow cells or preadipocytes populations in combination with RNA interference technology to specific transcription regulatory factors, it will be possible to isolate specific mesenchymal lineages for tissue repair. To achieve this, we describe a unique multidisciplinary research programme involving cell, molecular, proteomics and biophysical expertise that harnesses the potential of RNA interference technology to control cell lineages using bone formation as proof of concept. Protocols to isolate specific cell populations has widespread tissue engineering applications with significant healthcare implications.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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