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Investigation of differentially-regulated surface antigens in Eimeria tenella

Reference	BBS/B/04196
Principal Investigator / Supervisor	Professor Fiona Tomley
Co-Investigators / Co-Supervisors	Mr Enrique Tabares
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	232,983
Status	Completed
Type	Research Grant
Start date	18/10/2004
End date	17/10/2007
Duration	36 months

Abstract

Little is known about the expression of surface antigens (SAGs) in coccidian parasites. From more than 14,000 Eimeria tenella ESTs, we identified 37 genes that code for related, antigenically variant SAGs and showed experimentally that these are developmentally-regulated, GPI-linked surface proteins. We now propose to analyse the entire E. tenella SAG repertoire, which may include up to 250 different variants. We will investigate the genetic organisation, stage-regulation and differential expression of SAGs during the entire parasite life-cycle and determine whether E. tenella operates a model of antigenic switching or one of co-expression of multiple variants. We will also explore the potential role(s) that EtSAGs play in host-parasite interactions.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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