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Regulation of the clathrin coated vesicle cycle by rab5
Reference
BBS/B/04072
Principal Investigator / Supervisor
Professor Elizabeth Smythe
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Biomedical Science
Funding type
Research
Value (£)
193,473
Status
Completed
Type
Research Grant
Start date
14/04/2004
End date
13/04/2007
Duration
36 months
Abstract
Clathrin coated pits and vesicles are the first ports of entry into mammalian cells and represent a paradigm for membrane-based sorting events. Coated pits form from the directed assembly of coat proteins, clathrin and AP2, onto the membrane. Invagination and scission, which is at least partly mediated by dynamin, leads to coated vesicle formation. In addition to clathrin, AP2 and dynamin, a host of other proteins has been implicated in coated vesicle formation. The challenge lies in deciphering how the interactions of these proteins are regulated in space and time. Our laboratory has previously identified a novel role for the small GTPase rab5 in coated vesicle formation. Rab5 is a major regulator of endosomal dynamics and it appears that rab5 also plays key roles at the plasma membrane. The aim of this proposal is to elucidate how rab5 regulates the coated vesicle cycle.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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