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Mathematical analysis of regulation of limiting NF-kB activity

Reference	BBS/B/04056
Principal Investigator / Supervisor	Professor Eva Qwarnstrom
Co-Investigators / Co-Supervisors	Professor William Holcombe, Professor Rodney Smallwood
Institution	University of Sheffield
Department	Medicine and Biomedical Science
Funding type	Research
Value (£)	173,999
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

NF-KB, an evolutionary conserved signal transduction pathway, controls immune and inflammatory responses through Toll-like receptors. The pathway is tightly regulated by mechanisms involving turnover, directed trafficking and interactions of signalling components, and controlled through specific limiting steps. Our data show that increases in activity beyond those limited during normal pathway regulation are induced through phosphorylation of the subunit relA by the NF-KB inducing kinase, NIK, or the Ras GTP-ase. We will investigate the mechanisms of regulation of the non-limited feedback enhancement by continuous monitoring of signalling events in single live cells, and in real time. The data obtained will be used for detailed mathematical analysis and computational modelling of regulation of the NT-KB signalling network.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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