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Substrate specificity determinants of a regulatory protease

Reference	BBS/B/03955
Principal Investigator / Supervisor	Professor Dafydd Jones
Co-Investigators / Co-Supervisors
Institution	Cardiff University
Department	School of Biosciences
Funding type	Research
Value (£)	177,698
Status	Completed
Type	Research Grant
Start date	01/01/2004
End date	31/05/2007
Duration	41 months

Abstract

Over the past years, proteases serving regulatory functions receive increased attention. One, the DegS protein is involved in regulation of the bacterial unfolded protein response. It is a member of the HtrA family of widely conserved serine proteases that share a catalytic and at least one PDZ domain. In contrast to most other family members DegS has remarkable substrate specificity. Comparative structure-function studies are proposed to test various hypotheses addressing the molecular determinants of substrate specificity. As serine proteases and PDZ domains are widely distributed in nature and are involved in many key cellular processes these studies should yield biological information of general relevance.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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